This project aims at demonstrating the applicability of biophysical brain network models to neuropsychiatry. We will investigate the mechanisms underlying aberrant whole-brain functional connectivity observed in patients with SCZ using a computational neuro-platform named “The Virtual Brain” (TVB). Specifically, we aim to test the influence of changes in structural connectivity, excitation/inhibition balance, and random noise on whole-brain functional connectivity. Moreover, the derived model parameters will be related to neurochemical and genetic findings in SCZ.