Research theme

Computational modeling & generative agents

Brain-network simulations, symptom networks, digital twins and LLM-based agents.

Projects

Computational modeling of the functional connectome
This project aims at demonstrating the applicability of biophysical brain network models to neuropsychiatry. We will investigate the mechanisms underlying aberrant whole-brain functional connectivity observed in patients with SCZ using a computational neuro-platform named "The Virtual Brain" (TVB).
Symptom networks in psychotic and affective disorders
Psychiatric disorders are mainly defined by the occurrence of clinical symptoms such paranoia, social isolation or anxiety.
Digital Twins and Generative Agents in Mental Health
We develop computational "digital twins" of patients and generative AI agents to simulate mental health trajectories.

Publications

All in this theme

Blocking the reflection: Milestones and hurdles for digital twins in mental health

Verhees, F. G., Wiest, I. C., Kather, J. N., Kambeitz, J., Mikolas, P.

Pharmacopsychiatry · 2026

DOI for “Blocking the reflection: Milestones and hurdles for digital twins in mental health”

Observer-independent assessment of content overlap in mental health questionnaires: Large language model-based study

Böke, A., Hacker, H., Chakraborty, M., Baumeister-Lingens, L., Vöckel, J., Koenig, J., …, Lichtenstein, T. K., …, Kambeitz-Ilankovic, L., Kambeitz, J.

JMIR AI 4, e79868 · 2025

DOI for “Observer-independent assessment of content overlap in mental health questionnaires: Large language model-based study”

Computational modelling reveals neurobiological contributions to static and dynamic functional connectivity patterns

Hoheisel, L., Hacker, H., Fink, G. R., Daun, S., Kambeitz, J.

Front Comput Neurosci 19, 1525785 · 2025

DOI for “Computational modelling reveals neurobiological contributions to static and dynamic functional connectivity patterns”

The empirical structure of psychopathology is represented in large language models

Kambeitz, J., Schiffman, J., Kambeitz-Ilankovic, L., Mittal, V. A., Ettinger, U., Vogeley, K.

Nat Ment Health 3, 1482–1492 · 2025

DOI for “The empirical structure of psychopathology is represented in large language models”

Modelling the impact of environmental and social determinants on mental health using generative agents

Kambeitz, J., Meyer-Lindenberg, A.

NPJ Digit Med 8, 36 · 2025

DOI for “Modelling the impact of environmental and social determinants on mental health using generative agents”