FOCUS:

In order to understand mental health, it is crucial to consider the complex interplay of an individual with its environment. This includes biological and psychological factors as well as social interactions or the use of digital media. In our lab, we conduct research on this exciting field with the aim to:

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• identify adverse influences for mental health as well as protective factors 

• provide modern tools to allow individualised diagnostics and preventive strategies

• develop personalised interventions to support mental health

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METHODS:

Our team consists of a mix of methodologically-oriented clinicians and clinically-oriented methodologists, which allows us to live a close interaction between research and clinical application. Together we aim at the clinical translation of novel tools inspired by data-science oriented approaches such as:

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• machine-learning and big data analytics to identify informative patterns in behavioural or biological data

• network models to characterise complex relationships between symptoms, risk and protective factors

• dynamic systems modelling to provide a mechanistic understanding of brain in health and disease

• meta-analysis to address essential clinical questions based on a large body of evidence

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NEWS

TEAM MEMBERS

RESEARCH PROJECTS

TALKS

Check here for upcoming talks from invited speakers.

WORK WITH US

PUBLICATIONS

• Herstell S, Betz LT, Penzel N, Chechelnizki R, Filihagh L, Antonucci L, Kambeitz J (2021): Insecure attachment as a transdiagnostic risk factor for major psychiatric conditions: A meta-analysis in bipolar disorder, depression and schizophrenia spectrum disorder. J Psychiatr Res. 2021 Oct 11;144:190-201. doi: 10.1016/j.jpsychires.2021.10.002. Online ahead of print.PMID: 34678669
   

• Oeztuerk OF, Pigoni A, Wenzel J, Haas SS, Popovic D, Ruef A, Dwyer DB, Kambeitz-Ilankovic L, Ruhrmann S, Chisholm K, Lalousis P, Griffiths SL, Lichtenstein T, Rosen M, Kambeitz J, Schultze-Lutter F, Liddle P, Upthegrove R, Salokangas RKR, Pantelis C, Meisenzahl E, Wood SJ, Brambilla P, Borgwardt S, Falkai P, Antonucci LA, Koutsouleris N; PRONIA Consortium (2021): The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study. Eur Arch Psychiatry Clin Neurosci. 2021 Sep 17. doi: 10.1007/s00406-021-01327-y. Online ahead of print.PMID: 34535813
   

• Sanfelici R, Ruef A, Antonucci LA, Penzel N, Sotiras A, Dong MS, Urquijo-Castro M, Wenzel J, Kambeitz-Ilankovic L, Hettwer MD, Ruhrmann S, Chisholm K, Riecher-Rössler A, Falkai P, Pantelis C, Salokangas RKR, Lencer R, Bertolino A, Kambeitz J, Meisenzahl E, Borgwardt S, Brambilla P, Wood SJ, Upthegrove R, Schultze-Lutter F, Koutsouleris N, Dwyer DB; PRONIA Consortium (2021): Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness. Cereb Cortex. 2021 Sep 14:bhab288. doi: 10.1093/cercor/bhab288. Online ahead of print.PMID: 34519351
   

• Koutsouleris N, Worthington M, Dwyer DB, Kambeitz-Ilankovic L, Sanfelici R, Fusar-Poli P, Rosen M, Ruhrmann S, Anticevic A, Addington J, Perkins DO, Bearden CE, Cornblatt BA, Cadenhead KS, Mathalon DH, McGlashan T, Seidman L, Tsuang M, Walker EF, Woods SW, Falkai P, Lencer R, Bertolino A, Kambeitz J, Schultze-Lutter F, Meisenzahl E, Salokangas RKR, Hietala J, Brambilla P, Upthegrove R, Borgwardt S, Wood S, Gur RE, McGuire P, Cannon TD (2021): Toward Generalizable and Transdiagnostic Tools for Psychosis Prediction: An Independent Validation and Improvement of the NAPLS-2 Risk Calculator in the Multisite PRONIA Cohort. Biol Psychiatry. 2021 Nov 1;90(9):632-642. doi: 10.1016/j.biopsych.2021.06.023. Epub 2021 Jul 6.PMID: 34482951
   

• Haidl TK, Hedderich DM, Rosen M, Kaiser N, Seves M, Lichtenstein T, Penzel N, Wenzel J, Kambeitz-Ilankovic L, Ruef A, Popovic D, Schultze-Lutter F, Chisholm K, Upthegrove R, Salokangas RKR, Pantelis C, Meisenzahl E, Wood SJ, Brambilla P, Borgwardt S, Ruhrmann S, Kambeitz J, Koutsouleris N (2021): The non-specific nature of mental health and structural brain outcomes following childhood trauma. Psychol Med. 2021 Jul 6:1-10. doi: 10.1017/S0033291721002439
   

• Preuss UW, Huestis MA, Schneider M, Hermann D, Lutz B, Hasan A, Kambeitz J, Wong JWM, Hoch E (2021): Cannabis Use and Car Crashes: A Review. Front Psychiatry. 2021 May 28;12:643315. doi: 10.3389/fpsyt.2021.643315. eCollection 2021.
   

• Chamorro Y, Betz LT, Philipsen A, Kambeitz J, Ettinger U (2021): The Eyes Have It: A Meta-analysis of Oculomotor Inhibition in Attention-Deficit/Hyperactivity Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 May 27:S2451-9022(21)00144-0. doi: 10.1016/j.bpsc.2021.05.004.
   

• Goerigk SA, Padberg F, Chekroud A, Kambeitz J, Bühner M, Brunoni AR (2021): Parsing the antidepressant effects of non-invasive brain stimulation and pharmacotherapy: A symptom clustering approach on ELECT-TDCS. Brain Stimul. 2021 Jul-Aug;14(4):906-912. doi: 10.1016/j.brs.2021.05.008. Epub 2021 May 26.
   

• Hauke DJ, Schmidt A, Studerus E, Andreou C, Riecher-Rössler A, Radua J, Kambeitz J, Ruef A, Dwyer DB, Kambeitz-Ilankovic L, Lichtenstein T, Sanfelici R, Penzel N, Haas SS, Antonucci LA, Lalousis PA, Chisholm K, Schultze-Lutter F, Ruhrmann S, Hietala J, Brambilla P, Koutsouleris N, Meisenzahl E, Pantelis C, Rosen M, Salokangas RKR, Upthegrove R, Wood SJ, Borgwardt S; PRONIA Group (2021): Multimodal prognosis of negative symptom severity in individuals at increased risk of developing psychosis. Transl Psychiatry. 2021 May 24;11(1):312. doi: 10.1038/s41398-021-01409-4
   

• Haidl TK, Gruen M, Dizinger J, Rosen M, Doll CM, Penzel N, Daum L, Große Hokamp N, Klosterkötter J, Ruhrmann S, Vogeley K, Schultze-Lutter F, Kambeitz J (2021): Is there a diagnosis-specific influence of childhood trauma on later educational attainment? A machine learning analysis in a large help-seeking sample. J Psychiatr Res. 2021 Jun;138:591-597. doi: 10.1016/j.jpsychires.2021.04.040. Epub 2021 Apr 30.
   

• Padberg F, Bulubas L, Mizutani-Tiebel Y, Burkhardt G, Kranz GS, Koutsouleris N, Kambeitz J, Hasan A, Takahashi S, Keeser D, Goerigk S, Brunoni AR (2021): The intervention, the patient and the illness - Personalizing non-invasive brain stimulation in psychiatry. Exp Neurol. 2021 Jul;341:113713. doi: 10.1016/j.expneurol.2021.113713. Epub 2021 Mar 31.
   

• Lalousis PA, Wood SJ, Schmaal L, Chisholm K, Griffiths SL, Reniers RLEP, Bertolino A, Borgwardt S, Brambilla P, Kambeitz J, Lencer R, Pantelis C, Ruhrmann S, Salokangas RKR, Schultze-Lutter F, Bonivento C, Dwyer D, Ferro A, Haidl T, Rosen M, Schmidt A, Meisenzahl E, Koutsouleris N, Upthegrove R; PRONIA Consortium (2021): Heterogeneity and Classification of Recent Onset Psychosis and Depression: A Multimodal Machine Learning Approach. Schizophr Bull. 2021 Jul 8;47(4):1130-1140. doi: 10.1093/schbul/sbaa185.
   

• Antonucci LA, Penzel N, Pigoni A, Dominke C, Kambeitz J, Pergola G (2020): Flexible and specific contributions of thalamic subdivisions to human cognition. Neurosci Biobehav Rev. 2021 May;124:35-53. DOI: 10.1016/j.neubiorev.2021.01.014. Epub 2021 Jan 23.
   

• Wenzel J, Haas SS,  Dwyer DB, Ruef A, Oeztuerk OF, Antonucci LA, von Saldern S, Bonivento C, Garzitto M, Ferro A, Paolini M, Blautzik J, Borgwardt S, Brambilla P, Meisenzahl E, Salokangas RKR, Upthegrove R, Wood SJ, Kambeitz J, Koutsouleris N, Kambeitz-Ilankovic L, PRONIA consortium (2021): Cognitive subtypes in recent onset psychosis: distinct neurobiological fingerprints? Neuropsychopharmacology. DOI: https://doi.org/10.1038/s41386-021-00963-1
   

• Penzel N, Antonucci LA, Betz LT, Sanfelici R, Weiske J, Pogarell O, Cumming P, Quednow BB, Howes O, Falkai P, Upthegrove R, Bertolino A, Borgwardt S, Brambilla P, Lencer R, Meisenzahl E, Rosen M, Haidl T, Kambeitz-Ilankovic L, Ruhrmann S, Salokangas RRK, Pantelis C, Wood SJ, Koutsouleris N, Kambeitz J, PRONIA Consortium (2021): Association between age of cannabis initiation and gray matter covariance networks in recent onset psychosis. Neuropsychopharmacology. DOI: 10.1038/s41386-021-00977-9.
   

• Rosen M, Betz LT, Schultze-Lutter F, Chisholm K, Haidl TK, Kambeitz-Ilankovic L, Bertolino A, Borgwardt S, Brambilla P, Lencer R, Meisenzahl E, Ruhrmann S, Salokangas RKR, Upthegrove R, Wood SJ, Koutsouleris N, Kambeitz J, PRONIA Consortium (2021): Towards Clinical Application of Prediction Models for Transition to Psychosis: A Systematic Review and External Validation Study in the PRONIA Sample. Neurosci Biobehav Rev. 2021 Feb 23;S0149-7634(21)00086-5. DOI: 10.1016/j.neubiorev.2021.02.03
   

• Betz LT, Penzel N, Kambeitz-Ilankovic L, Rosen M, Chisholm K, Stainton A, Haidl TK, Wenzel J, Bertolino A, Borgwardt S, Brambilla P, Lencer R, Meisenzahl E, Ruhrmann S, Salokangas RKR, Schultze-Lutter F, Wood SJ, Upthegrove R, Koutsouleris N, Kambeitz J, PRONIA consortium (2020): General psychopathology links burden of recent life events and psychotic symptoms in a network approach. npj Schizophrenia volume 6, Article number: 40. DOI: https://doi.org/10.1038/s41537-020-00129-w
   

• Betz LT, Penzel N, Rosen M, Kambeitz J (2020): Relationships between childhood trauma and perceived stress in the general population: a network perspective. Psychol Med 1–11. DOI: 10.1017/S003329172000135X

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• Kambeitz J, Goerigk S, Gattaz W, Falkai P, Benseñor IM, Lotufo PA, et al. (2020): Clinical patterns differentially predict response to transcranial direct current stimulation (tDCS) and escitalopram in major depression: A machine learning analysis of the ELECT-TDCS study. J Affect Disord 265: 460–467. DOI: 10.1016/j.jad.2020.01.118

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• Proebstl L, Kamp F, Manz K, Krause D, Adorjan K, Pogarell O, ..., Kambeitz, J. (2019): Effects of stimulant drug use on the dopaminergic system: A systematic review and meta-analysis of in vivo neuroimaging studies. Eur Psychiatry 59: 15–24. DOI: 10.1016/j.eurpsy.2019.03.003

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• Kambeitz-Ilankovic L, Betz LT, Dominke C, Haas SS, Subramaniam K, Fisher M, et al. (2019): Multi-outcome meta-analysis (MOMA) of cognitive remediation in schizophrenia: Revisiting the relevance of human coaching and elucidating interplay between multiple outcomes. Neurosci Biobehav Rev 107: 828–845. DOI: 10.1016/j.neubiorev.2019.09.031

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• Kamp F, Proebstl L, Penzel N, Adorjan K, Ilankovic A, Pogarell O, ..., Kambeitz, J. (2019): Effects of sedative drug use on the dopamine system: a systematic review and meta-analysis of in vivo neuroimaging studies. Neuropsychopharmacology 44: 660–667. DOI: 10.1038/s41386-018-0191-9

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• Betz LT, Brambilla P, Ilankovic A, Premkumar P, Kim M-S, Raffard S, et al. (2019): Deciphering reward-based decision-making in schizophrenia: A meta-analysis and behavioral modeling of the Iowa Gambling Task. Schizophr Res 204: 7–15. DOI: 10.1016/j.schres.2018.09.009

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• Koutsouleris N, Kambeitz-Ilankovic L, Ruhrmann S, Rosen M, Ruef A, Dwyer DB, et al. (2018): Prediction Models of Functional Outcomes for Individuals in the Clinical High-Risk State for Psychosis or With Recent-Onset Depression: A Multimodal, Multisite Machine Learning Analysis. JAMA Psychiatry 75: 1156–1172. DOI: 10.1001/jamapsychiatry.2018.2165

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• Steffens M, Meyhöfer I, Fassbender K, Ettinger U, Kambeitz J (2018): Association of Schizotypy With Dimensions of Cognitive Control: A Meta-Analysis. Schizophr Bull 44: S512–S524. DOI: 10.1093/schbul/sby030

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• Kambeitz J, Cabral C, Sacchet MD, Gotlib IH, Zahn R, Serpa MH, et al. (2017): Detecting Neuroimaging Biomarkers for Depression: A Meta-analysis of Multivariate Pattern Recognition Studies. Biol Psychiatry 82: 330–338. DOI: 10.1016/j.biopsych.2016.10.028

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• Kambeitz J, la Fougère C, Werner N, Pogarell O, Riedel M, Falkai P, Ettinger U (2016): Nicotine-dopamine-transporter interactions during reward-based decision making. Eur Neuropsychopharmacol 26: 938–947. DOI: j.euroneuro.2016.03.011

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• Kambeitz J, Kambeitz-Ilankovic L, Cabral C, Dwyer DB, Calhoun VD, van den Heuvel MP, et al. (2016): Aberrant Functional Whole-Brain Network Architecture in Patients With Schizophrenia: A Meta-analysis. Schizophr Bull 42 Suppl 1: S13–21. DOI: 10.1093/schbul/sbv174

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For a complete list of publications, please click here.

ACKNOWLEDGEMENTS

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